5: Roll back Skyrim Special Edition Game.3: Add SKSE64 to the Exclusion List of the Antivirus Program.2: Allow SKSE64 through Windows Firewall.That requires you to check the version of the game. On the other hand, once the system detects that Skyrim Special Edition game is incompatible, it won’t allow it to run. So you need to grant access to this tool so that it can run on the latest Skyrim SE. In most cases, if the security software on your PC mistakes the SKSE64 as a threat, it will prohibit it from working. Anyway, the solutions below are the most relevant factors to this modding tool, so you would better move on. It is also said that the SKSE64 update failed. While some people showed that SKSE 64 suddenly doesn’t work on the latest Skyrim Special Edition game. Some users reported that after they allowed the SKSE64 executable file to create complex mods for games, the game can’t be launched. The SKSE64 errors vary from a user to another. But there are also complaints about SKSE 64 not working. Hence, for gamers, it is a dispensable tool to enjoy the game. Here mod in games refers to a kind of tool enabling gamers to agument or shape a game as they wish. SKSE64, short for The Skyrim Script Extender 64 tool, is a modding tool designed to create complex modes for games under Skyrim Special Edition.